winstrol

Perfalgan (paracetamol) has analgesic and antipyretic activity. The drug blocks cyclooxygenase I and II mainly in the central nervous system, acting on pain centers and thermoregulation. No effect on prostaglandin synthesis in peripheral tissues winstrol causes a lack of a negative effect on water-salt exchange (sodium and water retention) and the mucosa of the gastrointestinal tract.

Maximum plasma concentration is reached after IS minutes and is 15-30 mg / ml. The volume of distribution I l / kg. Paracetamol is poorly bound to plasma proteins, it crosses the blood-brain barrier.

It is metabolized in the liver to form the glucuronide and sulfate. A small portion (4%) of the drug is metabolized by cytochrome P450 to form an intermediate metabolite (N-atsetilbenzohinonimina), which in normal conditions quickly neutralized reduced glutathione and excreted in the urine after binding to the cysteine and merkaptopurinovoy acid. However, the quantity of this toxic metabolite is increased when massive intoxication. The half-life in adults is 2.7 hours in children – 1.5-2 hours, neonatal -3.5 h, total clearance of 18 l / h. Paracetamol is derived mainly from urine; 90% of the dose is excreted by the kidneys within 24 hours, mostly in the form glkzhuronida (60-80%) and sulfate (20-30%). Less than 5% is excreted unchanged. In severe renal insufficiency (creatinine clearance below 10-30 ml / min), elimination of paracetamol slows down somewhat, and the half-life of 2-5,3 hours. The elimination rate gyayukuronida and sulfate in patients with severe renal failure patients 3 times less than in healthy patients.

Indications

  • Syndrome winstrol pain of moderate intensity, particularly after surgery.
  • Feverish syndrome on the background of infectious and inflammatory diseases.
  • The drug is indicated for the rapid relief of pain and febrile syndrome, including when the oral route of administration is difficult.

Contraindications

  • Hypersensitivity to propatsetamolu hydrochloride or paracetamol (acetaminophen prodrug) or any other component of the formulation.
  • Severe liver dysfunction.
  • Children under 12 years old.

Be wary – severe renal insufficiency (creatinine clearance <30 mL / min), benign hyperbilirubinemia (including Gilbert’s syndrome, viral hepatitis, alcoholic liver disease), alcoholism, old age, lack of glucose-6-phosphate dehydrogenase.

Pregnancy and lactation

The drug should be used with caution during pregnancy and lactation.

Dosing and Administration

Single intravenous infusion over 15 minutes. Outdoor and unused medication should be discarded. Allowed additional dilution of 0.9% sodium chloride solution, maximum ten times. Such a diluted solution should be used within one hour after its winstrol preparation (including infusion time). cytover t3