The mechanism of action is to inhibit the synthesis and ergosterona membrane lipids (phospholipids and triglycerides) required for the synthesis of the cell wall of fungi (mushrooms lose their ability to form colonies and filament) and the violation cell wall permeability. It inhibits the transformation of Candida albicans blastospores into invasive form. Ketoconazole exhibit antifungal activity against anavar vs winstrol ovale and orbiculare, causing excessive scaling of the skin, it is also active against staphylococci and streptococci.
Absorption of the active ingredient through the skin when applied topically significantly. With prolonged use of ketoconazole in the blood is not determined;
Topical treatment of fungal infections caused by fungi sensitive to a drug: jock itch, athlete’s hands and feet, skin candidiasis, pityriasis versicolor, seborrheic dermatitis, caused by Pityrosporum ovale.
Ointment PERHOTAL should not be used in case of hypersensitivity to ketoconazole, in violation of the integrity of the skin in places intended application of ointment, for women during lactation.
As a result of clinical trials ketoconazole is detected in plasma, however, women during pregnancy should be taken with caution.
Dosing and Administration
In tinea skin (jock itch, athlete’s hands and feet, skin candidiasis and pityriasis versicolor) ointment applied directly to the affected and adjacent areas 1 time per day. In seborrheic dermatitis ointment applied to the affected area 2 times a day. The average duration of treatment is: tinea When smooth skin – 3-4 weeks with groin athlete – 2-4 weeks, with athlete’s foot – 4-6 weeks with infections caused by yeast fungi – 2-3 weeks, with pityriasis versicolor – 2 -3 weeks When seborrheic anavar vs winstrol dermatitis – 2-4 weeks.
The local application of ointment possible local allergic reactions such as burning, hives and skin rashes. In rare cases, a contact dermatitis.
Since the product is intended for external use only and is practically not absorbed into the systemic circulation, development of symptoms of overdose unlikely. In case of accidental admission into ointments should undertake to carry out gastric lavage and symptomatic treatment.
Interaction with other drugs
drug interactions anavar vs winstrol preparation for external use are not described.
The drug is intended for external use only, do not use in ophthalmic practice. Avoid contact with eyes ointment. When combined with the prolonged use of local dosage forms of glucocorticosteroids to prevent the development of the syndrome of “cancellation” it is recommended to use corticosteroids in the morning, and ointment in the evening, followed by gradual withdrawal of GCS in 2-3 weeks. During treatment should follow the general rules of hygiene. Information about the presence of any adverse effects from the missing children, efficacy and safety have not been established.